Sodium (Meta)Periodate

Sodium (Meta)Periodate - Names and Identifiers

Name	Sodium periodate
Synonyms	Sodium periodate Sodium Metapriodate Sodium Metaperiodate Sodium meta periodate Sodium (Meta)Periodate Sodium Tetroxoiodate(Vii) periodicacid(hio4),sodiumsalt sodiuM Metaperiodate in powder SODIUM METAPERIODATE FOR ANALYSIS EMSURE
CAS	7790-28-5
EINECS	232-197-6
InChI	InChI=1/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

Sodium (Meta)Periodate - Physico-chemical Properties

Molecular Formula	H2INaO4
Molar Mass	215.91
Density	3.865
Melting Point	300 °C (dec.) (lit.)
Boling Point	300°C
Water Solubility	80 g/L (20 ºC)
Solubility	H2O: 0.5M at20°C, clear, colorless
Vapor Presure	0Pa at 20℃
Appearance	Solid
Specific Gravity	4.174
Color	White to almost white
Odor	Odorless
Merck	14,8640
PH	3.5-5.5 (25℃, 0.5M in H2O)
Storage Condition	Store at +5°C to +30°C.
Stability	Stable. Incompatible with organic materials, combustible materials. Forms explosive mixtures with reducing agents, finely powdered metals, magnesium.
Sensitive	Hygroscopic
Physical and Chemical Properties	Properties colorless tetragonal crystal or white crystalline powder. relative density 4.174 solubility soluble in water, sulfuric acid, nitric acid and acetic acid, insoluble in alcohol.
Use	Used as pharmaceutical intermediates and health products

Sodium (Meta)Periodate - Risk and Safety

Risk Codes	R8 - Contact with combustible material may cause fire R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R50 - Very Toxic to aquatic organisms R48/25 - R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S17 - Keep away from combustible material. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37 - Wear suitable gloves.
UN IDs	UN 3087 5.1/PG 2
WGK Germany	3
RTECS	SD4550000
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	28299080
Hazard Class	5.1
Packing Group	II

Sodium (Meta)Periodate - Upstream Downstream Industry

Raw Materials

Iodine
Sodium Chloride

Sodium (Meta)Periodate - Nature

Open Data Verified Data

colorless or white crystalline powder, tetragonal. d16 3. 865. 300 C decomposition, soluble in cold water, sulfuric acid, nitric acid and acetic acid, insoluble in concentrated sodium hydroxide solution and ethanol. Its aqueous solution is produced by hydrolysis of H and HIO ~-; And acidic.

Last Update：2025-06-10 22:55:16

Sodium (Meta)Periodate - Preparation Method

Open Data Verified Data

chlorine oxidation method: the iodine is oxidized in an aqueous medium with chlorine gas to generate periodic acid. After separation, sodium hydroxide solution is added and neutralized to Ph 2-3 to generate Sodium periodate solution, after purification, separation of impurities, evaporation concentration, cooling crystallization, centrifugal separation, drying, prepared Sodium periodate product.

Last Update：2025-06-10 22:55:16

Sodium (Meta)Periodate - Application

Open Data Verified Data

may be used as an oxidizing agent. For ceramic paper, printed cloth, printing paper screen printing process; In the printing plate manufacturing process, for the removal of insoluble polyvinyl alcohol layer from the printing plate bottom. It is also used in the food and pharmaceutical industries.

Last Update：2025-08-19 16:24:40

Sodium (Meta)Periodate - Safety

Open Data Verified Data

has a irritating effect on the skin and eyes, should prevent contact with the skin and eyes. Staff should be protected and the workplace should be well ventilated. If you accidentally touch the skin and eyes, you should immediately rinse with a lot of water, and in severe cases, you should see a doctor. Should be stored in a cool, ventilated, dry, light-protected warehouse. The container should be sealed away from organic matter and other easily oxidized articles. It is not allowed to be stored and mixed with flammable and explosive articles. The application of railway carriage or other covered transport. When there is a fire, it can be suppressed by sand and carbon dioxide fire.

Last Update：2025-06-10 22:55:16

Sodium (Meta)Periodate - Reference Information

pH range of acid-base indicator discoloration	3.5 - 5.5
LogP	-1 at 20℃
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	Sodium periodate is a white tetragonal crystal that dissolves in water and acid. Contains trace amounts of free acid, chloride, bromide, sulfate, heavy metals and other impurities. Purification can be performed by recrystallization from an aqueous solution. This kind of goods has a strong oxidation performance, although it does not burn, but under certain conditions, subject to friction, vibration impact, high heat or acid and alkali substances, in the damp, contact with organic matter, when the reducing agent and the articles that conflict with the nature are mixed, they can be decomposed, and combustion and explosion occur.
Application	Sodium periodate has two main uses in Organic Synthesis: it is used as an oxidant and a catalyst. Due to the solubility, the oxidation of Sodium periodate is generally carried out in water. Since many organic substances are insoluble in water, the use of co-solvents is desirable. The oxidation reaction can also be carried out in a two-phase system when a phase transfer catalyst is present or Sodium periodate is supported on an inert support.
solubility in water (g/100ml)	grams dissolved per 100ml of water at different temperatures (℃): 1.83g/0 ℃;5.6g/10 ℃;10.3g/20 ℃;19.9g/30 ℃;30.4g/40 ℃
toxicity	has a irritating effect on the skin and eyes and should prevent contact with the skin and eyes. If you accidentally splash on the skin, wash it off with soap water; If you splash in the eyes, immediately rinse 15 mln with a large amount of water and ask a doctor for treatment. Should pay attention to dust. Wear work clothes, latex gloves, closed protective glasses, masks and other protective equipment during operation. Production equipment should be closed, ventilation should be good.
Use	may be used as an oxidizing agent. For ceramic paper, printed cloth, printing paper screen printing process; In the printing plate manufacturing process, for the removal of insoluble polyvinyl alcohol layer from the printing plate bottom. It is also used in the food and pharmaceutical industries. Sodium periodate can be used as an important raw material in the pharmaceutical industry, and can also be used as a common analytical reagent and chromatographic analysis reagent. used as pharmaceutical intermediates and health products quinone is produced by the cleavage of diols and the oxidation of hydroquinone.
production method	iodine is oxidized by chlorine gas in aqueous medium to form periodic acid, sodium periodate solution is generated by adding sodium hydroxide solution and neutralized to Ph 2~3, and then purified, separated impurities, concentrated by evaporation, cooled crystallization, centrifuged separation and dried to obtain Sodium periodate finished product, HIO4 NOH → NaIO4 H2O
category	oxidant
toxicity grade	high toxicity
Acute toxicity	intraperitoneal-mouse LD50: 58 mg/kg
explosive hazard characteristics	mixed with reductant, sulfur, phosphorus, etc, friction can burst
flammability hazard characteristics	toxic iodide and sodium oxide fumes from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is light and easy to discharge; It is combined with organic matter, reductant, sulfur and phosphorus combustible substances, separate storage of food raw materials
fire extinguishing agent	water, sand, foam
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)